Synthetic preparation process of a new type of refined guanidine hydrochloride

Guanidine hydrochloride is often used as an intermediate in medicines, pesticides, dyes and other organic compounds, it is also an important raw material for sulfonamides and folic acid; it can be used as a strong denaturants in the extraction of total RNA from cells. The proportion of traditional refined guanidine hydrochloride synthetic preparation process is simple, and the operation in each process is not strict: such as mixing impurities during stirring, temperature is difficult to observe, and weighing is inaccurate. Both of them lead to the problem that the low purity of the Guanidine HCL and the incomplete reaction. Then how to solve these problems?


Researchers have developed a new guanidine hydrochloride synthetic preparation process, which solves the shortcomings of the prior part. As a preference, the following steps are included:


1. Ratio: (1) dicyandiamide 350g, ammonium chloride 450g, ammonium carbonate 50g, (2) dicyandiamide 168g: ammonium chloride 203g: ammonium carbonate 19g; weighting by electronic precision balance, one prefabricated, another reserved.
2. Preparation, adding the pre-formed raw materials to the reaction kettle with electric heating function, adding the spare raw materials to the porcelain quality cup (high-temperature disinfection after washing and drying before operation), and uniformly stirring the raw materials in reaction kettle through the non-front glass rod. The raw materials in the porcelain cup are are added to the reaction kettle after the raw materials in that are uniformly stirred;
3, heating, the reactor is heated to 170°C±5°C, and monitored by a temperature sensor;
4. The synthesis reaction is carried out in a reactor environment of 170°C±5°C for three hours;

5. Preparation was completed, and the reaction vessel was opened to obtain 385 g of hydrazine hydrochloride.


The preparation process not only has a precise ratio, the reaction temperature is convenient for observation and control, no impurity is mixed during stirring, the reaction is complete, and the prepared guanidine hydrochloride is also high in purity.


Edited by Suzhou Yacoo Science Co., Ltd.