The effect of water on hydrolysis of N methyl pyrrolidone

At room temperature, due to the formation of hydrogen bonds between N-Methyl-2-Pyrrolidone and water, the hydrolysis rate of NMP is about 1%, and at high temperatures due to the destruction of hydrogen bonds, the hydrolysis rate of NMP remains at about 2.5%, so when only water is present in NMP The hydrolysis rate is small at both high temperature and room temperature. After adding NaOH, in the NMP containing NaOH solution at room temperature, water inhibits the hydrolysis of NMP to a certain extent, but after a certain amount, due to dissolution Partially non-ionized NaOH, the alkaline environment reduces the activation energy required for NMP to break the C-N bond, thereby intensifying the hydrolysis of NMP.

Through orthogonal experiments, it was found that because NMP hydrolysis needs to break the C-N bond to open the ring and needs to absorb energy, the temperature has the greatest impact on NMP hydrolysis.Secondly, the activation energy of NMP hydrolysis is reduced due to the alkaline environment caused by NaOH. NMP can achieve a higher hydrolysis rate at lower temperatures; the smallest factor that affects NMP hydrolysis is water.The formation of hydrogen bonds between water and NMP at low temperatures plays a role in protecting NMP, but at the high temperature, the presence of NaOH solution Under the influence of hydrogen bonds, the hydrolysis rate of NMP rises.