Crospovidone(PVPP) application

Crospovidone is a water-insoluble tablet disintegrating agent, used in direct compression and dry or wet granulation tableting process at a concentration of 2-5%; crospovidone can quickly exhibit high capillary activity and excellent water Chemical ability, almost no tendency to gel; studies have shown that: the size of crospovidone particles strongly affect the disintegration of antipyretic analgesic tablets, the larger particles of crospovidone can play a faster disintegration effect. Crospovidone is a very good disintegrant. It can be used in tablets for 1-2% to obtain the disintegration of other commonly used common disintegrants, and has good reworkability, that is, when recycling. There is no need to add a large amount of disintegrant, which is called a super disintegrant.
After the crospovidone is used as a disintegrant to form a tablet, the tablet has high hardness, short disintegration time limit, high dissolution rate, strong stability, and does not change over time.
PVPP can also be used as a dry adhesive, filler and excipient for tablets, capsules and granules. The smaller particle size can reduce the one-sided markings in tablets and improve the uniformity of tablets. The amount is 20-80 mg/tablet.
PVPP can also be used as a dissolution promoter. Co-evaporation technology can increase the solubility of poorly soluble drugs: firstly, the appropriate solvent is used to adsorb the drug to the crospovidone, and then the solvent is evaporated. This technique can be obtained faster. Dissolution rate.
This product is also widely used in the food industry as a filter aid for the production of wine and vinegar for the removal of enzymes and proteins.

PVPP and polyphenols form stable complexes that can be used to purify water-soluble or alcohol-containing herbal extracts and tinctures to improve the stability of botanicals. 
Hefei Teng Chao Chemical Material Co.,Ltd. is a mediumsized chemical corporation specialized in the manufacturing and sales of fine chemical materials. Our main products including Polyvinylpyrrolidone(PVP),2-Pyrrolidone,N-methylpyrrolidone ,Gamma-butyrolactone etc.

n methylpyrrolidone application is widely

N-methylpyrrolidone (NMP) is an N-methyl derivative of 2-pyrrolidone, which is a nitrogen heterocyclic compound and has a molecular formula of C5H9O. It is a high-boiling solvent for colorless to pale yellow transparent liquid. It has the characteristics of strong polarity, inertness, low viscosity, strong solubility, good stability, no corrosion, low volatility, etc. It has been applied in many fields such as medicine, food, daily chemical, textile, and detergent. Solvents mainly used in polymerization (such as polyamide, polyimide, polyurea, etc.), spinning solvents for synthetic fibers, solvents for processing functional resins into films

2-pyrrolidone application

2-pyrrolidone is miscible with water, alcohol, ether, chloroform, benzene, ethyl acetate and carbon disulfide; it is insoluble in petroleum ether, and its main use is as polyvinylpyrrolidone (PVP) monomer N-vinylpyrrolidone (NVP) The raw material is also a high-grade solvent, which is used in the production of pharmaceuticals, resins, acetylene recycling, and floor wax special inks. NVP can be prepared by reacting 2-pyrrolidone with acetylene and then polymerizing to obtain PVP. PVP has excellent solubility, low toxicity, film formation, complexation, surface activity and chemical stability, and is widely used in medicine, food, and day. In the fields of chemicals, coatings, polymer polymerization, etc., there are many uses in textiles, printing and dyeing, papermaking, photosensitive materials, agriculture and animal husbandry. There are three main industrial production routes for 2-pyrrolidone: 1) Rebec method: raw materials acetylene and formaldehyde are first reacted to form 1.4-butynediol, hydrogenated to 14-butanediol, converted to γ-butyrolactone, and then Ammonia is reacted to obtain 2-pyrrolidone. 2) Recently, due to the successful development of a new process for the oxidation of butane or 1.4-butanediol, the source of γ-butyrolactone is abundant, so it has become the main route for the production of pyrrolidone series products. It should be obtained as 1.4 dibutyl, partially hydrogenated to aminobutyronitrile, and hydrolyzed to 2-pyrrolidone.

2-pyrrolidone can be used as a high boiling point solvent for petroleum processing; to prepare N-vinylpyrrolidone, acrylonitrile, aminobutyric acid; also as a plasticizer for coatings; to form a polyamide under the action of benzoyl chloride and an alkali metal -4 and so on. 2-Pyrrolidone is a class of pyrrolidine compounds having a five-membered lactam ring, which is widely found in natural products and various synthetic compounds. Since pyrrolidone compounds have a wide variety of biological activities and are widely used in the field of medicine, many pyrididone structures can be modified and functionalized to prepare a plurality of compounds having various biological activities.